Physiopathology Of Parkinson Disease

Présentations de juniors sélectionnées

Chairs: E. Duplan, J-M Taymans

› Inhibition of glucocerebrosidase activity in a transgenic mice overexpressing alpha-synuclein - Elodie Cuvelier, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172 08:30-08:45 (15min)

› Resting state cortical oscillatory signatures of parkinsonian impulse control disorders pinpoint motor, executive dysfunctions. - Charlotte Spay, Centre de Recherche en Neurosciences de Lyon - Garance Meyer, Centre de Recherche en Neurosciences de Lyon 08:45-09:00 (15min)

› Does the stress protein TP53INP1 limit dopamine neuron death associated with normal ageing and Parkinson's disease ? - Emilie Dinh, Institut de Biologie du Développement de Marseille 09:00-09:15 (15min)

› Validation of protein phosphatases that regulate the LRRK2 phosphorylation cycle - Matthieu Drouyer, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172 09:15-09:30 (15min)

› Role of LRRK2 in mitochondrial function in Parkinson's disease: Focus on PINK1/Parkin-dependent mitophagy - Fiona Bonello, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute 09:30-09:45 (15min)

Présentations courtes d'opportunités de financement

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Pathophysiology explored in cellular and animal models : Drosophila models

Chairs: C. Alves da Costa, S. Hunot

› The role of mitochondrial calcium in PINK1/Parkin related Parkinson's disease - Alex Whitworth, MRC Mitochondrial Biology Unit, Cambridge 11:00-11:20 (20min)

› Causes and prevention of progressive locomotor disruption in a Drosophila model of Parkinson's disease - Serge Birman, Brain Plasticity Unit, ESPCI 11:20-11:40 (20min)

Pathophysiology explored in cellular and animal models : Neuroinflammation and immune system

Chairs: C. Alves da Costa, S. Hunot

› Neuro-immune interactions in Parkinson's disease: new insights from analysis of perivascular macrophage function - Stéphane Hunot, Institut du Cerveau et de la Moelle épinière 11:40-12:00 (20min)

› Impact of Parkin deficiency on inflammation in PD - François Mouton-Liger, Institut du Cerveau et de la Moelle épinière 12:00-12:20 (20min)

Towards neuroprotective / translational strategies: New tools for the cellular modeling

Chairs: D. Devos, H. Plun Favreau

› Genetics as an entrypoint for personalized medicine approaches in Parkinson's disease - Rejko Krüger, Université du Luxembourg 12:20-12:40 (20min)

› Human iPSC and microfluidics to model -synuclein propagation in neuronal networks - Simona Gribaudo, Institut des cellules souches pour le traitement et l'étude des maladies monogéniques 12:40-13:00 (20min)

Déjeuner / Posters

Towards neuroprotective / translational strategies: Preclinical tools and neuroprotective strategy

Chairs: D. Devos, H. Plun Favreau

› Ret protects the midbrain dopaminergic system against α-synuclein toxicity - Edgar Kramer, Plymouth University 14:20-14:40 (20min)

› Iron as a therapeutic target for Parkinson's disease - David Devos, Centre Hospitalier Régional Universitaire, Lille 14:40-15:00 (20min)

Towards neuroprotective / translational strategies: Potential biomarkers

Chairs: J-C Corvol, E. Mutez

› LRRK2 detection in urine exosomes as a potential biomarker of PD? - Jean-Marc Taymans, JPARC 15:00-15:20 (20min)

› Alpha-synuclein in the enteric nervous system: a predictive marker of PD? - Pascal Derkinderen, CHU Nantes 15:20-15:40 (20min)

› Prediction of PD progression and response to treatment - Jean-Christophe Corvol, Institut du Cerveau et de la Moelle épinière 15:40-16:00 (20min)

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