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lundi 23 avril 2018
| Heures | événement | |
| 08:30 - 09:10 | Bienvenue : objectif du symposium - Marie-Christine Chartier-Harlin - VIP de Lille, Florence Pasquier - LiCEND, Philippe Hantraye - NeurATRIS | |
| 09:10 - 10:30 | Human PD Pathophysiology - Brain imaging and therapeutic approach in clinic - Chairs: L. Defebvre, P. Hantraye | |
| 09:10 - 09:30 | › MRI and NMR in PD research - Stéphane Lehéricy, Institut du Cerveau et de la Moëlle Epinière (Brain and Spine Institute) | |
| 09:30 - 09:50 | › PET Imaging of PD patients - Philippe Rémy, CHU Henri Mondor | |
| 09:50 - 10:10 | › Deep brain stimulation for Parkinson's disease - Marie-Laure Welter, Hôpital de la Pitié-Salpêtrière - ICM | |
| 10:10 - 10:30 | › Novel therapeutic approach for PD: gene therapy - Stéphane Palfi, CHU Henri Mondor | |
| 10:30 - 11:00 | Pause café | |
| 11:00 - 12:45 | Human PD Pathophysiology - Genetics/Epigenetics/Gene-environment in PD - Chairs: E. Brouillet, M-C Chartier-Harlin | |
| 11:00 - 11:20 | › NGS in PD - Suzanne Lesage / Christelle Tesson, UMR_S1127 | |
| 11:20 - 11:40 | › Epigenetics, plasticity and neurodegenerative disorder - Anne-Laurence Boutillier, Laboratoire de Neurosciences Cognitives et Adaptatives | |
| 11:40 - 12:00 | › Deregulated pathways in PD Transcriptome - Marie-Christine Chartier-Harlin, Institut pour la recherche sur le cancer de Lille [Lille] | |
| 12:00 - 12:20 | › Gene-Environment interactions in Parkinson's disease - Alexis Elbaz, CHU Pitié-Salpêtrière [APHP] | |
| 12:45 - 14:30 | Déjeuner / Posters | |
| 14:30 - 15:30 | Pathophysiology explored in cellular and animal models - Alpha-synuclein, propagation - Chairs: B. Dehay, R. Melki | |
| 14:30 - 14:50 | › Structural, physical and functional properties of alpha-synuclein fibrils and their propagations in synucleinopathies - Ronald Melki, Neuro-PSI | |
| 14:50 - 15:10 | › Alpha-synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading - Chiara Zurzolo, Unité trafic membranaire et Pathogenèse, Institut Pasteur | |
| 15:10 - 15:30 | › Prion-like dissemination of synuclein pathology using human brain-derived alpha-synuclein in mice and monkeys - Erwan Bézard, Institut des Maladies Neurodégénératives, Bordeaux | |
| 15:30 - 16:50 | Pathophysiology explored in cellular and animal models - Modeling including other genetic factors - Chairs: E. Bézard, A. Elbaz | |
| 15:30 - 15:50 | › Functional interactions between alpha-synuclein and LRRK2 - Emmanuel Brouillet, UMR9199, MIRCen, Fontenay-aux-Roses | |
| 15:50 - 16:10 | › Pathobiology of LRRK2: where do we stand? - Elisa Greggio, Universita degli Studi di Padova | |
| 16:10 - 16:30 | › Lysosomal dysfunction in PD (SNCA, ATP13A2, GBA) - Benjamin Dehay, Institut des Maladies Neurodégénératives, Bordeaux | |
| 16:30 - 16:50 | › Mitophagy and beyond in autosomal recessive Parkinson's disease - Olga Corti, Institut du Cerveau et de la Moelle épinière (ICM), Paris | |
| 16:50 - 17:10 | Pause café | |
| 17:10 - 18:30 | Pathophysiology explored in cellular and animal models - Modeling including other genetic factors (2) - Chairs: M. Amalric, O. Corti | |
| 17:10 - 17:30 | › Mitophagy modulation as a potential therapeutic target for neurodegenerative diseases - Hélène Plun-Favreau, University College of London | |
| 17:30 - 17:50 | › Parkin transcription factor function in Parkinson's disease - Eric Duplan, IPMC, Nice | |
| 17:50 - 18:10 | › Gating of basal ganglia functions by striatal cholinergic interneurons in experimental parkinsonism - Nicolas Maurice, IBDML, Marseille | |
| 18:10 - 18:30 | › Optogenetic to regulate neuronal activity: modulation of striatal cholinergic interneurons and muscarinic receptors as targets in rodent models of Parkinson's disease - Marianne Amalric, Laboratoire de Neurosciences Cognitives | |
| 18:30 - 19:00 | Pause | |
| 19:00 - 20:00 | Conférence ouverte au public : "Les maladies de Parkinson, quelles perspectives ?" - Yves Agid |
mardi 24 avril 2018
| Heures | événement | |
| 08:30 - 10:00 | Présentations de juniors sélectionnées - Chairs: E. Duplan, J-M Taymans | |
| 08:30 - 08:45 | › Inhibition of glucocerebrosidase activity in a transgenic mice overexpressing alpha-synuclein - Elodie Cuvelier, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172 | |
| 08:45 - 09:00 | › Resting state cortical oscillatory signatures of parkinsonian impulse control disorders pinpoint motor, executive dysfunctions. - Charlotte Spay, Centre de Recherche en Neurosciences de Lyon - Garance Meyer, Centre de Recherche en Neurosciences de Lyon | |
| 09:00 - 09:15 | › Does the stress protein TP53INP1 limit dopamine neuron death associated with normal ageing and Parkinson's disease ? - Emilie Dinh, Institut de Biologie du Développement de Marseille | |
| 09:15 - 09:30 | › Validation of protein phosphatases that regulate the LRRK2 phosphorylation cycle - Matthieu Drouyer, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172 | |
| 09:30 - 09:45 | › Role of LRRK2 in mitochondrial function in Parkinson's disease: Focus on PINK1/Parkin-dependent mitophagy - Fiona Bonello, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute | |
| 10:00 - 10:30 | Présentations courtes d'opportunités de financement | |
| 10:30 - 11:00 | Pause café | |
| 11:00 - 11:40 | Pathophysiology explored in cellular and animal models : Drosophila models - Chairs: C. Alves da Costa, S. Hunot | |
| 11:00 - 11:20 | › The role of mitochondrial calcium in PINK1/Parkin related Parkinson's disease - Alex Whitworth, MRC Mitochondrial Biology Unit, Cambridge | |
| 11:20 - 11:40 | › Causes and prevention of progressive locomotor disruption in a Drosophila model of Parkinson's disease - Serge Birman, Brain Plasticity Unit, ESPCI | |
| 11:40 - 12:20 | Pathophysiology explored in cellular and animal models : Neuroinflammation and immune system - Chairs: C. Alves da Costa, S. Hunot | |
| 11:40 - 12:00 | › Neuro-immune interactions in Parkinson's disease: new insights from analysis of perivascular macrophage function - Stéphane Hunot, Institut du Cerveau et de la Moelle épinière | |
| 12:00 - 12:20 | › Impact of Parkin deficiency on inflammation in PD - François Mouton-Liger, Institut du Cerveau et de la Moelle épinière | |
| 12:20 - 13:00 | Towards neuroprotective / translational strategies: New tools for the cellular modeling - Chairs: D. Devos, H. Plun Favreau | |
| 12:20 - 12:40 | › Genetics as an entrypoint for personalized medicine approaches in Parkinson's disease - Rejko Krüger, Université du Luxembourg | |
| 12:40 - 13:00 | › Human iPSC and microfluidics to model α-synuclein propagation in neuronal networks - Simona Gribaudo, Institut des cellules souches pour le traitement et l'étude des maladies monogéniques | |
| 13:00 - 14:20 | Déjeuner / Posters | |
| 14:20 - 15:00 | Towards neuroprotective / translational strategies: Preclinical tools and neuroprotective strategy - Chairs: D. Devos, H. Plun Favreau | |
| 14:20 - 14:40 | › Ret protects the midbrain dopaminergic system against α-synuclein toxicity - Edgar Kramer, Plymouth University | |
| 14:40 - 15:00 | › Iron as a therapeutic target for Parkinson's disease - David Devos, Centre Hospitalier Régional Universitaire, Lille | |
| 15:00 - 16:00 | Towards neuroprotective / translational strategies: Potential biomarkers - Chairs: J-C Corvol, E. Mutez | |
| 15:00 - 15:20 | › LRRK2 detection in urine exosomes as a potential biomarker of PD? - Jean-Marc Taymans, JPARC | |
| 15:20 - 15:40 | › Alpha-synuclein in the enteric nervous system: a predictive marker of PD? - Pascal Derkinderen, CHU Nantes | |
| 15:40 - 16:00 | › Prediction of PD progression and response to treatment - Jean-Christophe Corvol, Institut du Cerveau et de la Moelle épinière | |
| 16:00 - 16:15 | Pause café | |
| 16:15 - 16:30 | Prix du meilleur poster et de la meilleure présentation, clôture |
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