Program

Week Mon. 23 Tue. 24 List

	Mon. 23	Tue. 24
08:00 09:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 18:00 19:00 20:00	Welcome: Objective of the Symposium 8:30 - 9:10 (40min) Welcome: Objective of the Symposium Marie-Christine Chartier-Harlin - VIP de Lille, Florence Pasquier - LiCEND, Philippe Hantraye - NeurATRIS Human PD Pathophysiology - Brain imaging and therapeutic approach in clinic 9:10 - 10:30 (1h20) Human PD Pathophysiology - Brain imaging and therapeutic approach in clinic Chairs: L. Defebvre, P. Hantraye › MRI and NMR in PD research - Stéphane Lehéricy, Institut du Cerveau et de la Moëlle Epinière (Brain and Spine Institute) 09:10-09:30 (20min) › PET Imaging of PD patients - Philippe Rémy, CHU Henri Mondor 09:30-09:50 (20min) › Deep brain stimulation for Parkinson's disease - Marie-Laure Welter, Hôpital de la Pitié-Salpêtrière - ICM 09:50-10:10 (20min) › Novel therapeutic approach for PD: gene therapy - Stéphane Palfi, CHU Henri Mondor 10:10-10:30 (20min) Coffee break 10:30 - 11:00 (30min) Coffee break Human PD Pathophysiology - Genetics/Epigenetics/Gene-environment in PD 11:00 - 12:45 (1h45) Human PD Pathophysiology - Genetics/Epigenetics/Gene-environment in PD Chairs: E. Brouillet, M-C Chartier-Harlin › NGS in PD - Suzanne Lesage / Christelle Tesson, UMR_S1127 11:00-11:20 (20min) › Epigenetics, plasticity and neurodegenerative disorder - Anne-Laurence Boutillier, Laboratoire de Neurosciences Cognitives et Adaptatives 11:20-11:40 (20min) › Deregulated pathways in PD Transcriptome - Marie-Christine Chartier-Harlin, Institut pour la recherche sur le cancer de Lille [Lille] 11:40-12:00 (20min) › Gene-Environment interactions in Parkinson's disease - Alexis Elbaz, CHU Pitié-Salpêtrière [APHP] 12:00-12:20 (20min) Lunch / Posters 12:45 - 14:30 (1h45) Lunch / Posters Pathophysiology explored in cellular and animal models - Alpha-synuclein, propagation 14:30 - 15:30 (1h) Pathophysiology explored in cellular and animal models - Alpha-synuclein, propagation Chairs: B. Dehay, R. Melki › Structural, physical and functional properties of alpha-synuclein fibrils and their propagations in synucleinopathies - Ronald Melki, Neuro-PSI 14:30-14:50 (20min) › Alpha-synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading - Chiara Zurzolo, Unité trafic membranaire et Pathogenèse, Institut Pasteur 14:50-15:10 (20min) › Prion-like dissemination of synuclein pathology using human brain-derived alpha-synuclein in mice and monkeys - Erwan Bézard, Institut des Maladies Neurodégénératives, Bordeaux 15:10-15:30 (20min) Pathophysiology explored in cellular and animal models - Modeling including other genetic factors 15:30 - 16:50 (1h20) Pathophysiology explored in cellular and animal models - Modeling including other genetic factors Chairs: E. Bézard, A. Elbaz › Functional interactions between alpha-synuclein and LRRK2 - Emmanuel Brouillet, UMR9199, MIRCen, Fontenay-aux-Roses 15:30-15:50 (20min) › Pathobiology of LRRK2: where do we stand? - Elisa Greggio, Universita degli Studi di Padova 15:50-16:10 (20min) › Lysosomal dysfunction in PD (SNCA, ATP13A2, GBA) - Benjamin Dehay, Institut des Maladies Neurodégénératives, Bordeaux 16:10-16:30 (20min) › Mitophagy and beyond in autosomal recessive Parkinson's disease - Olga Corti, Institut du Cerveau et de la Moelle épinière (ICM), Paris 16:30-16:50 (20min) Coffee break 16:50 - 17:10 (20min) Coffee break Pathophysiology explored in cellular and animal models - Modeling including other genetic factors (2) 17:10 - 18:30 (1h20) Pathophysiology explored in cellular and animal models - Modeling including other genetic factors (2) Chairs: M. Amalric, O. Corti › Mitophagy modulation as a potential therapeutic target for neurodegenerative diseases - Hélène Plun-Favreau, University College of London 17:10-17:30 (20min) › Parkin transcription factor function in Parkinson's disease - Eric Duplan, IPMC, Nice 17:30-17:50 (20min) › Gating of basal ganglia functions by striatal cholinergic interneurons in experimental parkinsonism - Nicolas Maurice, IBDML, Marseille 17:50-18:10 (20min) › Optogenetic to regulate neuronal activity: modulation of striatal cholinergic interneurons and muscarinic receptors as targets in rodent models of Parkinson's disease - Marianne Amalric, Laboratoire de Neurosciences Cognitives 18:10-18:30 (20min) Break 18:30 - 19:00 (30min) Break Conference open to the public : "Les maladies de Parkinson, quelles perspectives ?" 19:00 - 20:00 (1h) Conference open to the public : "Les maladies de Parkinson, quelles perspectives ?" Yves Agid	Oral presentation of juniors selected on their abstracts 8:30 - 10:00 (1h30) Oral presentation of juniors selected on their abstracts Chairs: E. Duplan, J-M Taymans › Inhibition of glucocerebrosidase activity in a transgenic mice overexpressing alpha-synuclein - Elodie Cuvelier, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172 08:30-08:45 (15min) › Resting state cortical oscillatory signatures of parkinsonian impulse control disorders pinpoint motor, executive dysfunctions. - Charlotte Spay, Centre de Recherche en Neurosciences de Lyon - Garance Meyer, Centre de Recherche en Neurosciences de Lyon 08:45-09:00 (15min) › Does the stress protein TP53INP1 limit dopamine neuron death associated with normal ageing and Parkinson's disease ? - Emilie Dinh, Institut de Biologie du Développement de Marseille 09:00-09:15 (15min) › Validation of protein phosphatases that regulate the LRRK2 phosphorylation cycle - Matthieu Drouyer, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172 09:15-09:30 (15min) › Role of LRRK2 in mitochondrial function in Parkinson's disease: Focus on PINK1/Parkin-dependent mitophagy - Fiona Bonello, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute 09:30-09:45 (15min) Short presentations of funding opportunities 10:00 - 10:30 (30min) Short presentations of funding opportunities Coffee break 10:30 - 11:00 (30min) Coffee break Pathophysiology explored in cellular and animal models : Drosophila models 11:00 - 11:40 (40min) Pathophysiology explored in cellular and animal models : Drosophila models Chairs: C. Alves da Costa, S. Hunot › The role of mitochondrial calcium in PINK1/Parkin related Parkinson's disease - Alex Whitworth, MRC Mitochondrial Biology Unit, Cambridge 11:00-11:20 (20min) › Causes and prevention of progressive locomotor disruption in a Drosophila model of Parkinson's disease - Serge Birman, Brain Plasticity Unit, ESPCI 11:20-11:40 (20min) Pathophysiology explored in cellular and animal models : Neuroinflammation and immune system 11:40 - 12:20 (40min) Pathophysiology explored in cellular and animal models : Neuroinflammation and immune system Chairs: C. Alves da Costa, S. Hunot › Neuro-immune interactions in Parkinson's disease: new insights from analysis of perivascular macrophage function - Stéphane Hunot, Institut du Cerveau et de la Moelle épinière 11:40-12:00 (20min) › Impact of Parkin deficiency on inflammation in PD - François Mouton-Liger, Institut du Cerveau et de la Moelle épinière 12:00-12:20 (20min) Towards neuroprotective / translational strategies: New tools for the cellular modeling 12:20 - 13:00 (40min) Towards neuroprotective / translational strategies: New tools for the cellular modeling Chairs: D. Devos, H. Plun Favreau › Genetics as an entrypoint for personalized medicine approaches in Parkinson's disease - Rejko Krüger, Université du Luxembourg 12:20-12:40 (20min) › Human iPSC and microfluidics to model α-synuclein propagation in neuronal networks - Simona Gribaudo, Institut des cellules souches pour le traitement et l'étude des maladies monogéniques 12:40-13:00 (20min) Lunch / Posters 13:00 - 14:20 (1h20) Lunch / Posters Towards neuroprotective / translational strategies: Preclinical tools and neuroprotective strategy 14:20 - 15:00 (40min) Towards neuroprotective / translational strategies: Preclinical tools and neuroprotective strategy Chairs: D. Devos, H. Plun Favreau › Ret protects the midbrain dopaminergic system against α-synuclein toxicity - Edgar Kramer, Plymouth University 14:20-14:40 (20min) › Iron as a therapeutic target for Parkinson's disease - David Devos, Centre Hospitalier Régional Universitaire, Lille 14:40-15:00 (20min) Towards neuroprotective / translational strategies: Potential biomarkers 15:00 - 16:00 (1h) Towards neuroprotective / translational strategies: Potential biomarkers Chairs: J-C Corvol, E. Mutez › LRRK2 detection in urine exosomes as a potential biomarker of PD? - Jean-Marc Taymans, JPARC 15:00-15:20 (20min) › Alpha-synuclein in the enteric nervous system: a predictive marker of PD? - Pascal Derkinderen, CHU Nantes 15:20-15:40 (20min) › Prediction of PD progression and response to treatment - Jean-Christophe Corvol, Institut du Cerveau et de la Moelle épinière 15:40-16:00 (20min) Coffee break 16:00 - 16:15 (15min) Coffee break Poster and oral prices, closing remarks 16:15 - 16:30 (15min) Poster and oral prices, closing remarks

Online user: 1