Physiopathology Of Parkinson Disease

Bienvenue : objectif du symposium

Marie-Christine Chartier-Harlin - VIP de Lille, Florence Pasquier - LiCEND, Philippe Hantraye - NeurATRIS

Human PD Pathophysiology - Brain imaging and therapeutic approach in clinic

Chairs: L. Defebvre, P. Hantraye

› MRI and NMR in PD research - Stéphane Lehéricy, Institut du Cerveau et de la Moëlle Epinière (Brain and Spine Institute) 09:10-09:30 (20min)

› PET Imaging of PD patients - Philippe Rémy, CHU Henri Mondor 09:30-09:50 (20min)

› Deep brain stimulation for Parkinson's disease - Marie-Laure Welter, Hôpital de la Pitié-Salpêtrière - ICM 09:50-10:10 (20min)

› Novel therapeutic approach for PD: gene therapy - Stéphane Palfi, CHU Henri Mondor 10:10-10:30 (20min)

Pause café

Human PD Pathophysiology - Genetics/Epigenetics/Gene-environment in PD

Chairs: E. Brouillet, M-C Chartier-Harlin

› NGS in PD - Suzanne Lesage / Christelle Tesson, UMR_S1127 11:00-11:20 (20min)

› Epigenetics, plasticity and neurodegenerative disorder - Anne-Laurence Boutillier, Laboratoire de Neurosciences Cognitives et Adaptatives 11:20-11:40 (20min)

› Deregulated pathways in PD Transcriptome - Marie-Christine Chartier-Harlin, Institut pour la recherche sur le cancer de Lille [Lille] 11:40-12:00 (20min)

› Gene-Environment interactions in Parkinson's disease - Alexis Elbaz, CHU Pitié-Salpêtrière [APHP] 12:00-12:20 (20min)

Déjeuner / Posters

Pathophysiology explored in cellular and animal models - Alpha-synuclein, propagation

Chairs: B. Dehay, R. Melki

› Structural, physical and functional properties of alpha-synuclein fibrils and their propagations in synucleinopathies - Ronald Melki, Neuro-PSI 14:30-14:50 (20min)

› Alpha-synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading - Chiara Zurzolo, Unité trafic membranaire et Pathogenèse, Institut Pasteur 14:50-15:10 (20min)

› Prion-like dissemination of synuclein pathology using human brain-derived alpha-synuclein in mice and monkeys - Erwan Bézard, Institut des Maladies Neurodégénératives, Bordeaux 15:10-15:30 (20min)

Pathophysiology explored in cellular and animal models - Modeling including other genetic factors

Chairs: E. Bézard, A. Elbaz

› Functional interactions between alpha-synuclein and LRRK2 - Emmanuel Brouillet, UMR9199, MIRCen, Fontenay-aux-Roses 15:30-15:50 (20min)

› Pathobiology of LRRK2: where do we stand? - Elisa Greggio, Universita degli Studi di Padova 15:50-16:10 (20min)

› Lysosomal dysfonctions in PD (SNCA, ATP13A2, GBA) - Benjamin Dehay, Institut des Maladies Neurodégénératives, Bordeaux 16:10-16:30 (20min)

› Mitophagy and beyond in autosomal recessive Parkinson's disease - Olga Corti, Institut du Cerveau et de la Moelle épinière (ICM), Paris 16:30-16:50 (20min)

Pause café

Pathophysiology explored in cellular and animal models - Modeling including other genetic factors (2)

Chairs: M. Amalric, O. Corti

› Mitophagy modulation as a potential therapeutic target for neurodegenerative diseases - Hélène Plun-Favreau, University College of London 17:10-17:30 (20min)

› Parkin transcription factor function in Parkinson's disease - Eric Duplan, IPMC, Nice 17:30-17:50 (20min)

› Gating of basal ganglia functions by striatal cholinergic interneurons in experimental parkinsonism - Nicolas Maurice, IBDML, Marseille 17:50-18:10 (20min)

› Optogenetic to regulate neuronal activity: the example of muscarinic receptor as target for controlling striatal activity in PD models - Marianne Amalric, Laboratoire de Neurosciences Cognitives 18:10-18:30 (20min)

Pause

Conférence ouverte au public : "Les maladies de Parkinson, quelles perspectives ?"

Yves Agid