Program
| Time |
Event |
(+)
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08:30 - 09:10
|
Welcome: Objective of the Symposium - Marie-Christine Chartier-Harlin - VIP de Lille, Florence Pasquier - LiCEND, Philippe Hantraye - NeurATRIS |
|
|
09:10 - 10:30
|
Human PD Pathophysiology - Brain imaging and therapeutic approach in clinic - Chairs: L. Defebvre, P. Hantraye |
(+)
|
| 09:10 - 09:30 |
› MRI and NMR in PD research - Stéphane Lehéricy, Institut du Cerveau et de la Moëlle Epinière (Brain and Spine Institute) |
|
| 09:30 - 09:50 |
› PET Imaging of PD patients - Philippe Rémy, CHU Henri Mondor |
|
| 09:50 - 10:10 |
› Deep brain stimulation for Parkinson's disease - Marie-Laure Welter, Hôpital de la Pitié-Salpêtrière - ICM |
|
| 10:10 - 10:30 |
› Novel therapeutic approach for PD: gene therapy - Stéphane Palfi, CHU Henri Mondor |
|
|
10:30 - 11:00
|
Coffee break |
|
|
11:00 - 12:45
|
Human PD Pathophysiology - Genetics/Epigenetics/Gene-environment in PD - Chairs: E. Brouillet, M-C Chartier-Harlin |
(+)
|
| 11:00 - 11:20 |
› NGS in PD - Suzanne Lesage / Christelle Tesson, UMR_S1127 |
|
| 11:20 - 11:40 |
› Epigenetics, plasticity and neurodegenerative disorder - Anne-Laurence Boutillier, Laboratoire de Neurosciences Cognitives et Adaptatives |
|
| 11:40 - 12:00 |
› Deregulated pathways in PD Transcriptome - Marie-Christine Chartier-Harlin, Institut pour la recherche sur le cancer de Lille [Lille] |
|
| 12:00 - 12:20 |
› Gene-Environment interactions in Parkinson's disease - Alexis Elbaz, CHU Pitié-Salpêtrière [APHP] |
|
|
12:45 - 14:30
|
Lunch / Posters |
|
|
14:30 - 15:30
|
Pathophysiology explored in cellular and animal models - Alpha-synuclein, propagation - Chairs: B. Dehay, R. Melki |
(+)
|
| 14:30 - 14:50 |
› Structural, physical and functional properties of alpha-synuclein fibrils and their propagations in synucleinopathies - Ronald Melki, Neuro-PSI |
|
| 14:50 - 15:10 |
› Alpha-synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading - Chiara Zurzolo, Unité trafic membranaire et Pathogenèse, Institut Pasteur |
|
| 15:10 - 15:30 |
› Prion-like dissemination of synuclein pathology using human brain-derived alpha-synuclein in mice and monkeys - Erwan Bézard, Institut des Maladies Neurodégénératives, Bordeaux |
|
|
15:30 - 16:50
|
Pathophysiology explored in cellular and animal models - Modeling including other genetic factors - Chairs: E. Bézard, A. Elbaz |
(+)
|
| 15:30 - 15:50 |
› Functional interactions between alpha-synuclein and LRRK2 - Emmanuel Brouillet, UMR9199, MIRCen, Fontenay-aux-Roses |
|
| 15:50 - 16:10 |
› Pathobiology of LRRK2: where do we stand? - Elisa Greggio, Universita degli Studi di Padova |
|
| 16:10 - 16:30 |
› Lysosomal dysfunction in PD (SNCA, ATP13A2, GBA) - Benjamin Dehay, Institut des Maladies Neurodégénératives, Bordeaux |
|
| 16:30 - 16:50 |
› Mitophagy and beyond in autosomal recessive Parkinson's disease - Olga Corti, Institut du Cerveau et de la Moelle épinière (ICM), Paris |
|
|
16:50 - 17:10
|
Coffee break |
|
|
17:10 - 18:30
|
Pathophysiology explored in cellular and animal models - Modeling including other genetic factors (2) - Chairs: M. Amalric, O. Corti |
(+)
|
| 17:10 - 17:30 |
› Mitophagy modulation as a potential therapeutic target for neurodegenerative diseases - Hélène Plun-Favreau, University College of London |
|
| 17:30 - 17:50 |
› Parkin transcription factor function in Parkinson's disease - Eric Duplan, IPMC, Nice |
|
| 17:50 - 18:10 |
› Gating of basal ganglia functions by striatal cholinergic interneurons in experimental parkinsonism - Nicolas Maurice, IBDML, Marseille |
|
| 18:10 - 18:30 |
› Optogenetic to regulate neuronal activity: modulation of striatal cholinergic interneurons and muscarinic receptors as targets in rodent models of Parkinson's disease - Marianne Amalric, Laboratoire de Neurosciences Cognitives |
|
|
18:30 - 19:00
|
Break |
|
|
19:00 - 20:00
|
Conference open to the public : "Les maladies de Parkinson, quelles perspectives ?" - Yves Agid |
|
| Time |
Event |
(+)
|
|
08:30 - 10:00
|
Oral presentation of juniors selected on their abstracts - Chairs: E. Duplan, J-M Taymans |
(+)
|
| 08:30 - 08:45 |
› Inhibition of glucocerebrosidase activity in a transgenic mice overexpressing alpha-synuclein - Elodie Cuvelier, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172 |
|
| 08:45 - 09:00 |
› Resting state cortical oscillatory signatures of parkinsonian impulse control disorders pinpoint motor, executive dysfunctions. - Charlotte Spay, Centre de Recherche en Neurosciences de Lyon - Garance Meyer, Centre de Recherche en Neurosciences de Lyon |
|
| 09:00 - 09:15 |
› Does the stress protein TP53INP1 limit dopamine neuron death associated with normal ageing and Parkinson's disease ? - Emilie Dinh, Institut de Biologie du Développement de Marseille |
|
| 09:15 - 09:30 |
› Validation of protein phosphatases that regulate the LRRK2 phosphorylation cycle - Matthieu Drouyer, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc) - U1172 |
|
| 09:30 - 09:45 |
› Role of LRRK2 in mitochondrial function in Parkinson's disease: Focus on PINK1/Parkin-dependent mitophagy - Fiona Bonello, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute |
|
|
10:00 - 10:30
|
Short presentations of funding opportunities |
|
|
10:30 - 11:00
|
Coffee break |
|
|
11:00 - 11:40
|
Pathophysiology explored in cellular and animal models : Drosophila models - Chairs: C. Alves da Costa, S. Hunot |
(+)
|
| 11:00 - 11:20 |
› The role of mitochondrial calcium in PINK1/Parkin related Parkinson's disease - Alex Whitworth, MRC Mitochondrial Biology Unit, Cambridge |
|
| 11:20 - 11:40 |
› Causes and prevention of progressive locomotor disruption in a Drosophila model of Parkinson's disease - Serge Birman, Brain Plasticity Unit, ESPCI |
|
|
11:40 - 12:20
|
Pathophysiology explored in cellular and animal models : Neuroinflammation and immune system - Chairs: C. Alves da Costa, S. Hunot |
(+)
|
| 11:40 - 12:00 |
› Neuro-immune interactions in Parkinson's disease: new insights from analysis of perivascular macrophage function - Stéphane Hunot, Institut du Cerveau et de la Moelle épinière |
|
| 12:00 - 12:20 |
› Impact of Parkin deficiency on inflammation in PD - François Mouton-Liger, Institut du Cerveau et de la Moelle épinière |
|
|
12:20 - 13:00
|
Towards neuroprotective / translational strategies: New tools for the cellular modeling - Chairs: D. Devos, H. Plun Favreau |
(+)
|
| 12:20 - 12:40 |
› Genetics as an entrypoint for personalized medicine approaches in Parkinson's disease - Rejko Krüger, Université du Luxembourg |
|
| 12:40 - 13:00 |
› Human iPSC and microfluidics to model α-synuclein propagation in neuronal networks - Simona Gribaudo, Institut des cellules souches pour le traitement et l'étude des maladies monogéniques |
|
|
13:00 - 14:20
|
Lunch / Posters |
|
|
14:20 - 15:00
|
Towards neuroprotective / translational strategies: Preclinical tools and neuroprotective strategy - Chairs: D. Devos, H. Plun Favreau |
(+)
|
| 14:20 - 14:40 |
› Ret protects the midbrain dopaminergic system against α-synuclein toxicity - Edgar Kramer, Plymouth University |
|
| 14:40 - 15:00 |
› Iron as a therapeutic target for Parkinson's disease - David Devos, Centre Hospitalier Régional Universitaire, Lille |
|
|
15:00 - 16:00
|
Towards neuroprotective / translational strategies: Potential biomarkers - Chairs: J-C Corvol, E. Mutez |
(+)
|
| 15:00 - 15:20 |
› LRRK2 detection in urine exosomes as a potential biomarker of PD? - Jean-Marc Taymans, JPARC |
|
| 15:20 - 15:40 |
› Alpha-synuclein in the enteric nervous system: a predictive marker of PD? - Pascal Derkinderen, CHU Nantes |
|
| 15:40 - 16:00 |
› Prediction of PD progression and response to treatment - Jean-Christophe Corvol, Institut du Cerveau et de la Moelle épinière |
|
|
16:00 - 16:15
|
Coffee break |
|
|
16:15 - 16:30
|
Poster and oral prices, closing remarks |
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